SPHINX31
| CAS号 | 1818389-84-2 | 货号 | BCP30381 |
| 中文名 | SPHINX31 | ||
| 英文名 | SPHINX31 | ||
| 中文别名 | |||
| 英文别名 | SPHINX 31;SPHINX-31; | ||
| 分子式 | C27H24F3N5O2 | 分子量 | 507.51 |
| 生物活性 | SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM).It is selective for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells. In vivo, SPHINX31 (2 μg per eye) inhibits blood vessel growth and macrophage infiltration in the eyes of a mouse model of choroidal neovascularization. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | SRPK | ||
结构式
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