LOXO-101 HCl salt
| CAS No. | 1919868-83-9 | Cat. No. | BCP30585 |
| Name | LOXO-101 HCl salt | ||
| Synonyms | LOXO101 HCl salt；LOXO 101 HCl salt；Larotrectinib HCl;LOXO-101 Hydrochloric; | ||
| Formula | C21H23ClF2N6O2 | M. Wt | 464.90 |
| Description | LOXO-101 is an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Trk Receptor | ||
Structure
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