TR-14035
| CAS号 | 232271-19-1 | 货号 | BCP30639 |
| 中文名 | TR-14035 | ||
| 英文名 | TR-14035 | ||
| 中文别名 | |||
| 英文别名 | TR 14035; TR14035;MDK-1191; MDK1191; MDK 1191; SB683698; SB 683698; SB-683698; QJ-2620; | ||
| 分子式 | C24H21Cl2NO5 | 分子量 | 474.33 |
| 生物活性 | TR14035 blocked the binding of human alpha(4)beta(7) to an (125)I-MAdCAM-Ig fusion protein with IC(50) values of 0.75 nM. TR14035 blocked binding of human alpha(4)beta(7)-expressing RPMI-8866 cells or murine mesenteric lymph node lymphocytes to MAdCAM-Ig with IC(50) values of 0.1 microM. TR14035 blocked adhesion to HEVs [ED(50) of 0.01-0.1 mpk i.v.]. TR-14035 was taken up by rat and human hepatocytes by an apparently single saturable mechanism with K(m) of 6.7 and 2.1 microM, respectively, and taurocholate and digoxin reduced this uptake. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | Integrin | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！