UAMC3203 3HCl
| CAS No. | UAMC32033HCl | Cat. No. | BCP30685 |
| Name | UAMC3203 3HCl | ||
| Synonyms | UAMC 3203 3HCl;UAMC-3203 3HCl; | ||
| Formula | C25H40Cl3N5O2S | M. Wt | 581.04 |
| Description | UAMC-3203 is a Ferroptosis Inhibitor wtih IC50 = 12 nM. UAMC-3203 showed an improved protection compared to Fer-1 against multiorgan injury in mice. No toxicity was observed in mice after daily injection of 39 (UAMC-3203) for 4 weeks. UAMC-3203 inserts rapidly in a phospholipid bilayer in silico, which aligns with the current understanding of the mechanism of action of these compounds. In conclusion, these analogues have superior properties compared to Fer-1, show in vivo efficacy, and represent novel lead compounds with therapeutic potential in relevant ferroptosis-driven disease models. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | Ferroptosis | ||
Structure
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