COH000
| CAS No. | 1534358-79-6 | Cat. No. | BCP31057 |
| Name | COH000 | ||
| Synonyms | COH-000; COH 000; | ||
| Formula | C25H25NO5 | M. Wt | 419.48 |
| Description | COH000 is a highly specific covalent allosteric SUMO E1 inhibitor with an IC50 of 0.2 μM for SUMOylation in vitro. COH000 targets a cryptic pocket distinct from the active site that is completely buried in all previous SUMO E1 structures and that COH000 binding to SUMO E1 is accompanied by a network of structural changes that altogether lock the enzyme in a previously unobserved inactive conformation. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | E1 E2 E3 Enzyme | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.