C-178
| CAS No. | 329198-87-0 | Cat. No. | BCP31292 |
| Name | C-178 | ||
| Synonyms | C 178;C178;STING inhibitor C-178; | ||
| Formula | C17H10N2O5 | M. Wt | 322.27 |
| Description | C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING). | ||
| Pathways | Others Pathway | ||
| Targets | STING | ||
Structure
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