Treosulfa
| CAS No. | 299-75-2 | Cat. No. | BCP31509 |
| Name | Treosulfa | ||
| Synonyms | NSC 39069; NSC39069; NSC-39069;Treosulphan;Ovastat; | ||
| Formula | C6H14O8S2 | M. Wt | 278.301 |
| Description | Treosulfan is the product of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppresive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhbits myeloablative and immunosuppressive activities. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA Alkylator/Crosslinker | ||
Structure
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