ANI-7
| CAS No. | 931417-26-4 | Cat. No. | BCP31623 |
| Name | ANI-7 | ||
| Synonyms | ANI 7;ANI7; | ||
| Formula | C13H8Cl2N2 | M. Wt | 263.12 |
| Description | ANI-7 is a potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway; inhibits other cell lines derived from other tumour types with GI50 of 3.2-46 uM (lung, colon, ovary, neuronal, glial, prostate, and pancreas); potently inhibits the growth of T47D, ZR-75-1, MCF-7, SKBR3, and MDA-MB-468 breast cancer cells with GI50 of 0.16-0.38 uM, induces cell cycle arrest checkpoint activation and DNA damage; binds to the AhR, induces translocation to the nucleus, activates the XRE, induces CYP1 activity, culminating in cell cycle arrest, checkpoint activation, DNA damage and cell death. | ||
| Pathways | Others Pathway | ||
| Targets | AhR | ||
Structure
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