BM-1197
| CAS No. | 1391107-89-3 | Cat. No. | BCP31671 |
| Name | BM-1197 | ||
| Synonyms | BM1197；BM 1197; | ||
| Formula | C53H59ClF4N6O7S4 | M. Wt | 1131.77 |
| Description | BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1; exerts potent growth-inhibitory activity in 7 of 12 small cell lung cancer cell lines tested and induces mechanism-based apoptotic cell death, induces complete and long-lasting tumor regression in vivo. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | Bcl2 | ||
Structure
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