KDOAM-25
| CAS No. | 2230731-99-2 | Cat. No. | BCP31703 |
| Name | KDOAM-25 | ||
| Synonyms | KDOAM25;KDOAM 25; | ||
| Formula | C15H25N5O2 | M. Wt | 307.39 |
| Description | KDOAM-25 is a potent, selective KDM5 sub-family(JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively; weakly inhibits KDM4C/KDM2B (IC50=4.8/4.4 uM) and good selectivity over other demethylases; most potently inhibits KDM5B (IC50=50 uM) and increases H3K4me3 levels in Hela cells; increases global H3K4 methylation, causes G1 cell-cycle arrest and impairs cell proliferation in multiple myeloma MM1S cells. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Demethylase | ||
Structure
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