TH-257
| CAS No. | 2244678-29-1 | Cat. No. | BCP31775 |
| Name | TH-257 | ||
| Synonyms | TH257; TH 257; | ||
| Formula | C24H26N2O3S | M. Wt | 422.54 |
| Description | TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | LIMK | ||
Structure
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