AZ304
CAS No. | 942507-42-8 | Cat. No. | BCP31900 |
Name | AZ304 | ||
Synonyms | AZ-304; AZ 304; | ||
Formula | C27H25N5O2 | M. Wt | 451.53 |
Description | AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79 nM and 38 nM, respectively. | ||
Pathways | Others Pathway MAPK Pathway | ||
Targets | Autophagy Raf |
Structure
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