AZ304

  • Chemical Properties
CAS No. 942507-42-8 Cat. No. BCP31900
Name AZ304
Synonyms AZ-304; AZ 304;
Formula C27H25N5O2 M. Wt 451.53
  • Biological Activity
Description AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79 nM and 38 nM, respectively.
Pathways Others Pathway MAPK Pathway 
Targets Autophagy Raf 

Structure

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