BTRX-335140
| CAS No. | 2244614-14-8 | Cat. No. | BCP32121 |
| Name | BTRX-335140 | ||
| Synonyms | BTRX 335140; BTRX335140; CYM-53093; CYM 53093; CYM53093; | ||
| Formula | C25H33FN5O2 | M. Wt | 454.56 |
| Description | BTRX-335140, also known as CYM-53093, a potent and selective KOR antagonist with IC50 (KOR)=0.8 nM. BTRX-335140 endowed with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rat pharmacodynamic experiments. Orally administered CYM-53093 showed robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick analgesia in mice. CYM-53093 exhibited a broad selectivity over a panel of off-target proteins. | ||
| Pathways | Neuro Signaling Pathway Hormone Pathay GPCR/G Protein | ||
| Targets | Opioid Receptor | ||
Structure
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