PK68
| CAS No. | 2173556-69-7 | Cat. No. | BCP32187 |
| Name | PK68 | ||
| Synonyms | PK-68;PK 68; | ||
| Formula | C22H24N4O3S | M. Wt | 424.52 |
| Description | PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and with great potential for use in the treatment of inflammatory disorders and cancer metastasis. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | RIP | ||
Structure
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