GIBH-130
| CAS号 | 1252608-59-5 | 货号 | BCP32635 |
| 中文名 | GIBH-130 | ||
| 英文名 | GIBH-130 | ||
| 中文别名 | |||
| 英文别名 | GIBH 130; GIBH130; | ||
| 分子式 | C20H20N6O | 分子量 | 360.41 |
| 生物活性 | GIBH-130 is a neuroinflammation inhibitor. GIBH-130 exhibited comparable in vivo efficacy of cognitive impairment relief to donepezil and memantine respectively in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models at a substantially lower dose (0.25 mg/kg). Therefore, GIBH-130 constitutes a unique chemical probe for pathogenesis research and drug development of AD, and it also suggests microglia-based phenotypic screenings that target neuroinflammation as an effective and feasible strategy to identify novel anti-AD agents. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | Interleukin Related | ||
结构式
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