NVS-ZP7-4
| CAS号 | 2349367-89-9 | 货号 | BCP32718 |
| 中文名 | NVS-ZP7-4 | ||
| 英文名 | NVS-ZP7-4 | ||
| 中文别名 | |||
| 英文别名 | NVS-ZP7 4; NVS-ZP74; NVSZP7-4; NVSZP7 4; NVSZP74; | ||
| 分子式 | C28H28FN5OS | 分子量 | 501.62 |
| 生物活性 | NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of the compound photoaffinity labeled ZIP7 in cells, suggesting a direct interaction between the compound and ZIP7. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. | ||
| 信号通路 | Wnt/Stem Cell | ||
| 靶 点 | Notch | ||
结构式
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