CL2A-SN-38
| CAS号 | 1279680-68-0 | 货号 | BCP32728 |
| 中文名 | CL2A-SN-38 | ||
| 英文名 | CL2A-SN-38 | ||
| 中文别名 | |||
| 英文别名 | |||
| 分子式 | C73H97N11O22 | 分子量 | 1480.61 |
| 生物活性 | CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a nonclaevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | ADC Related | ||
|
A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors
购于瀚香生物(Biochempartner)的CL2A-SN-38(CAS:1279680-68-0)被引用 |
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