PTC299
CAS No. | 1256565-36-2 | Cat. No. | BCP32869 |
Name | PTC299 | ||
Synonyms | PTC-299;PTC 299; | ||
Formula | C25H20Cl2N2O3 | M. Wt | 467.34 |
Description | PTC299 is a potent, orally bioavailable VEGFA inhibitor, targets dihydroorotate dehydrogenase (DHODH), resulting in cell growth inhibition and differentiation in leukemias, including acute myeloid leukemia, linking DHODH regulation and stress-induced VEGFA and angiogenesis. | ||
Pathways | Angiogenesis/Protein Tyrosine Kinase Cell Cycle/DNA Damage | ||
Targets | DNA/RNA Synthesis VEGFR |
Structure
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