KI696
| CAS号 | 1799974-70-1 | 货号 | BCP33044 |
| 中文名 | KI696 | ||
| 英文名 | KI696 | ||
| 中文别名 | |||
| 英文别名 | KI-696; KI 696; | ||
| 分子式 | C28H30N4O6S | 分子量 | 550.63 |
| 生物活性 | KI-696 is a novel chemical probe for KEAP1 and Inhibitor of KEAP1-NRF2 protein-protein interaction. KI-696 represents an excellent LMW tool to study the KEAP1-NRF2 interaction in vivo. Discovered by FBS, the probe is well characterised in a number of in vitro assays as well as showing robust in vivo effects. The in vivo application is hampered by low bioavailability and high clearance, necessitating IV infusions as the mode of administration, which may limit the usefulness of the probe in vivo. | ||
| 信号通路 | NFκB | ||
| 靶 点 | Keap1 Nrf2 | ||
结构式
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