Tamoxifen

  • Chemical Properties
CAS No. 10540-29-1 Cat. No. BCP33248
Name Tamoxifen
Synonyms ICI 46474; ICI-46474; ICI46474; (Z)-Tamoxifen; trans-Tamoxifen;
Formula C26H29NO M. Wt 371.51
  • Biological Activity
Description Tamoxifen is a selective estrogen receptor modulator (SERM) and antagonist of ER action in breast tissue and breast cancer cells. It is reported to be effective in the treatment of early breast cancer to prevent tumor growth. Importantly, tamoxifen has been reported to act as an ER agonist in bone and blood vessels, helping to minimize osteoporosis and reduce the risk of cardiovascular disease in post-menopausal women. Also, tamoxifen is a partial ER agonist in uterine tissues and is reported to increase the risk of endometrial carcinoma.
Pathways Protease/Metabolic Enzyme Cell Cycle/DNA Damage Hormone Pathay 
Targets Estrogen Receptor HSP 

Structure

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