Rapalink-1
| CAS No. | Rapalink-1 | Cat. No. | BCP33282 |
| Name | Rapalink-1 | ||
| Synonyms | |||
| Formula | C91H138N12O24 | M. Wt | 1784.14 |
| Description | RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 (a second-generation mTOR kinase inhibitor) by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. Anticancer activity. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | mTOR | ||
Structure
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