泼尼卡酯
| CAS号 | 73771-04-7 | 货号 | BCP33443 |
| 中文名 | 泼尼卡酯 | ||
| 英文名 | Prednicarbate | ||
| 中文别名 | 泼尼卡松; | ||
| 英文别名 | Hoe 777; Hoe-777;Dermatop;Regemt; | ||
| 分子式 | C27H36O8 | 分子量 | 488.57 |
| 生物活性 | Prednicarbate is a synthetic non-halogenated double-ester derivative of the corticosteroid prednisolone with anti-inflammatory, antipruritic and vasoconstrictive properties. Following skin permeation, prednicarbate enters cells and binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of pro-inflammatory cytokine production by increasing the expression of lipocortins. These block phospholipase A-dependent release of arachidonic acid thereby inhibiting prostaglandin synthesis. This agent also decreases the number of circulating lymphocytes by suppression of the production of vasodilators such as prostacyclin and nitric oxide. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Glucocorticoid Receptor | ||
结构式
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