盐酸美法仑
| CAS号 | 3223-07-2 | 货号 | BCP33593 |
| 中文名 | 盐酸美法仑 | ||
| 英文名 | Melphalan Hydrochloride | ||
| 中文别名 | 左旋苯丙氨酸氮芥; | ||
| 英文别名 | Melphalan HCl;L-Sarcolysine hydrochloride;CB 3025 hydrochloride; | ||
| 分子式 | C13H19Cl3N2O2 | 分子量 | 341.66 |
| 生物活性 | Melphalan Hydrochloride is a bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA Alkylator/Crosslinker | ||
结构式
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