伊万卡赛

  • 化学数据
CAS号 870964-67-3 货号 BCP33803
中文名 伊万卡赛
英文名 Evocalcet
中文别名 伊万卡塞;
英文别名 MT-4580; MT 4580; MT4580; KHK-7580; KHK7580; KHK 7580;
分子式 C24H26N2O2 分子量 374.48
  • 用途
生物活性 Evocalcet is a calcium-sensing receptor agonist. The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. The calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone (PTH). CaSR is expressed in all of the organs of the digestive system. CaSR plays a key role in gastrointestinal physiological function and in the occurrence of digestive disease. High dietary Ca2+ may stimulate CaSR activation and could both inhibit tumor development and increase the chemotherapeutic sensitivity of cancer cells in colon cancer tissues.
信号通路 GPCR/G Protein 
靶 点 CaSR 

结构式

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