伊万卡赛
CAS号 | 870964-67-3 | 货号 | BCP33803 |
中文名 | 伊万卡赛 | ||
英文名 | Evocalcet | ||
中文别名 | 伊万卡塞; | ||
英文别名 | MT-4580; MT 4580; MT4580; KHK-7580; KHK7580; KHK 7580; | ||
分子式 | C24H26N2O2 | 分子量 | 374.48 |
生物活性 | Evocalcet is a calcium-sensing receptor agonist. The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. The calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone (PTH). CaSR is expressed in all of the organs of the digestive system. CaSR plays a key role in gastrointestinal physiological function and in the occurrence of digestive disease. High dietary Ca2+ may stimulate CaSR activation and could both inhibit tumor development and increase the chemotherapeutic sensitivity of cancer cells in colon cancer tissues. | ||
信号通路 | GPCR/G Protein | ||
靶 点 | CaSR |
结构式

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