LMP744 hydrochloride
| CAS No. | 308246-57-3 | Cat. No. | BCP34016 |
| Name | LMP744 hydrochloride | ||
| Synonyms | LMP-744 hydrochloride; LMP-744 HCl; LMP744 HCl; LMP 744 HCl;MJ-III65 hydrochloride; NSC706744 hydrochloride; | ||
| Formula | C24H25ClN2O7 | M. Wt | 488.92 |
| Description | LMP-744 hydrochloride is a DNA intercalator and topoisomerase inhibitor with antitumor activity. LMP-744 HCl produces persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Consistent with Top1 poisoning, protein-linked DNA breaks were detected in cells treated with LMP-744 HCl at nanomolar concentrations. Studies in human cells in culture found LMP-744 HCl to be cytotoxic. Furthermore, limited cross-resistance was observed in camptothecin-resistant cell lines. LMP-744 HCl also exhibits antitumor activity in mouse tumor xenografts. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Topoisomerase | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.