E-Guggulsterone
| CAS No. | 39025-24-6 | Cat. No. | BCP34834 |
| Name | E-Guggulsterone | ||
| Synonyms | Guggulsterone E; | ||
| Formula | C21H28O2 | M. Wt | 312.45 |
| Description | Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | AKT | ||
Structure
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