CCMI
| CAS No. | 917837-54-8 | Cat. No. | BCP35052 |
| Name | CCMI | ||
| Synonyms | AVL-3288; AVL 3288; AVL3288; XY-4083; XY 4083; XY4083; Anvylic-3288; UCI-4083; UCI4083; UCI 4083; | ||
| Formula | C19H15Cl2N3O2 | M. Wt | 388.25 |
| Description | CCMI is a first-in-class, orally available, small molecule, selective allosteric modulator of the alpha7 nicotinic acetylcholine receptor (α7 nAChR). AVL-3288 has shown preclinical efficacy in rat paradigms of attention and memory, including models of cognitive dysfunction1-3. AVL-3288 evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). AVL-3288 exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons. | ||
| Pathways | Ion Channel/Membrane Transporter Neuro Signaling Pathway | ||
| Targets | nAChR | ||
Structure
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