MSA-2
| CAS No. | 129425-81-6 | Cat. No. | BCP35448 |
| Name | MSA-2 | ||
| Synonyms | MSA2;MSA 2;5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-Butanoic Acid; | ||
| Formula | C14H14O5S | M. Wt | 294.32 |
| Description | MSA-2 is an orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models. | ||
| Pathways | Others Pathway | ||
| Targets | STING | ||
Structure
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