舒夫戈利
| CAS号 | 308831-61-0 | 货号 | BCP35686 |
| 中文名 | 舒夫戈利 | ||
| 英文名 | Sufugolix | ||
| 中文别名 | |||
| 英文别名 | TAK-013; TAK013; TAK 013; | ||
| 分子式 | C36H31F2N5O4S | 分子量 | 667.73 |
| 生物活性 | Sufugolix is a non-peptide, orally-active, selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (IC50 = 0.1 and 0.06 nM for affinity and in vitro inhibition, respectively). It was under development for the treatment of endometriosis and uterine leiomyoma and reached phase II clinical trials for both of these indications, but was subsequently discontinued. It seems to have been supplanted by relugolix (TAK-385), which is also under development by Takeda for the treatment of these conditions and has a more favorable drug profile (including reduced cytochrome P450 inhibition and improved in vivo GnRHR antagonistic activity) in comparison. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Glucagon Receptor | ||
结构式
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