Golexanolone
| CAS No. | 2089238-18-4 | Cat. No. | BCP36048 |
| Name | Golexanolone | ||
| Synonyms | GR-3027; GR 3027; GR3027; | ||
| Formula | C21H31NO2 | M. Wt | 329.48 |
| Description | Golexanolone, also known as GR-3027, is a neurosteroid medication which is under development for the treatment of hypersomnia and hepatic encephalopathy. It acts as a negative allosteric modulator of the GABAA receptor. The medication selectively antagonizes the stimulatory actions of inhibitory neurosteroids like allopregnanolone and tetrahydrodeoxycorticosterone (THDOC) at the GABAA receptor, while not affecting the activation of the GABAA receptor by γ-aminobutyric acid (GABA). | ||
| Pathways | Ion Channel/Membrane Transporter Neuro Signaling Pathway | ||
| Targets | GABA Receptor | ||
Structure
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