依喜替康甲磺酸盐二水合物
| CAS号 | 197720-53-9 | 货号 | BCP36302 |
| 中文名 | 依喜替康甲磺酸盐二水合物 | ||
| 英文名 | Exatecan mesylate dihydrate | ||
| 中文别名 | |||
| 英文别名 | DX 8951; DX-8951; DX8951; | ||
| 分子式 | C25H32FN3O9S | 分子量 | 567.58 |
| 生物活性 | Exatecan Mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Topoisomerase | ||
结构式
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