Opelconazole
| CAS号 | 1931946-73-4 | 货号 | BCP36481 |
| 中文名 | Opelconazole | ||
| 英文名 | Opelconazole | ||
| 中文别名 | |||
| 英文别名 | PC 945;PC-945;PC945; | ||
| 分子式 | C38H37F3N6O3 | 分子量 | 682.73 |
| 生物活性 | PC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively; shows MIC values 0.032 to >8 ug/ml against 96 clinically isolated A. fumigatus strains, demonstrates activity against itraconazole-susceptible and -resistant A. fumigatus growth with IC50 of 0.0012 to 0.034 ug/ml; PC945 is a broad spectrum of pathogenic fungi with MIC 0.0078 to 2 ug/ml, and exhibits activity in vivo. | ||
| 信号通路 | Protease/Metabolic Enzyme Microbiology/Virology | ||
| 靶 点 | Cytochrome P450 Antifungal | ||
结构式
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