Selumetinib sulfate
CAS No. | 943332-08-9 | Cat. No. | BCP36547 |
Name | Selumetinib sulfate | ||
Synonyms | AZD-6244 sulfate;AZD 6244 sulfate;AZD6244 sulfate; ARRY-142886 sulfate; | ||
Formula | C17H17BrClFN4O7S | M. Wt | 555.76 |
Description | Selumetinib Sulfate is the sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers. | ||
Pathways | MAPK Pathway | ||
Targets | MEK/ERK |
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.