氟轻松
| CAS号 | 807-38-5 | 货号 | BCP36573 |
| 中文名 | 氟轻松 | ||
| 英文名 | Fluocinolone | ||
| 中文别名 | |||
| 英文别名 | 6-alpha-Fluorotriamcinolone; | ||
| 分子式 | C21H26F2O6 | 分子量 | 412.42 |
| 生物活性 | Fluocinolone is a synthetic glucocorticoid with anti-inflammatory and antipruritic activities. Fluocinolone binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinolone that interacts with and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinolone binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Glucocorticoid Receptor | ||
结构式
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