BB-Cl-Amidine hydrochloride

化学数据

CAS号	BB-Cl-AmidineHCl	货号	BCP36632
中文名	BB-Cl-Amidine hydrochloride
英文名	BB-Cl-Amidine hydrochloride
中文别名
英文别名	BB-Cl-Amidine HCl;
分子式	C26H27Cl2N5O	分子量	496.43

用途

生物活性	BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.BB-Cl-Amidine is a Novel Therapeutic for Canine and Feline Mammary Cancer via Activation of the Endoplasmic Reticulum Stress Pathway. BB-Cl-Amidine is a modified version of Cl-amidine that retains the functional components but possesses a C-terminal benzimidazole group designed to limit proteolysis of the C-terminal amide. BB-CLA reduced viability and tumorigenicity of canine and feline mammary cancer cell lines in vitro. BB-CLA activates the endoplasmic reticulum stress pathway in these cells by downregulating 78 kDa Glucose-regulated Protein (GRP78), a potential target in breast cancer for molecular therapy, and upregulating the downstream target gene DNA Damage Inducible Transcript 3 (DDIT3).

生物活性

BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.BB-Cl-Amidine is a Novel Therapeutic for Canine and Feline Mammary Cancer via Activation of the Endoplasmic Reticulum Stress Pathway. BB-Cl-Amidine is a modified version of Cl-amidine that retains the functional components but possesses a C-terminal benzimidazole group designed to limit proteolysis of the C-terminal amide. BB-CLA reduced viability and tumorigenicity of canine and feline mammary cancer cell lines in vitro. BB-CLA activates the endoplasmic reticulum stress pathway in these cells by downregulating 78 kDa Glucose-regulated Protein (GRP78), a potential target in breast cancer for molecular therapy, and upregulating the downstream target gene DNA Damage Inducible Transcript 3 (DDIT3).

结构式

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