Namitecan
| CAS号 | 372105-27-6 | 货号 | BCP36777 |
| 中文名 | Namitecan | ||
| 英文名 | Namitecan | ||
| 中文别名 | |||
| 英文别名 | ST-1968; ST 1968; ST1968; | ||
| 分子式 | C23H22N4O5 | 分子量 | 434.45 |
| 生物活性 | Namitecan, also known as ST-1968, is a new water-soluble camptothecin analogue which showed high antitumor activity in preclinical models. ST1968 exhibited an impressive activity against several tumors including models of ovarian and colon carcinoma in which a high rate of cures was observed. t ST1968 was able to overcome the most relevant mechanisms associated with the development of topotecan resistance (i.e., slow proliferation and target downregulation) owing to its peculiar pharmacokinetic behaviour. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Topoisomerase | ||
结构式
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