Adavivint

  • Chemical Properties
CAS No. 1467013-03-3 Cat. No. BCP36799
Name Adavivint
Synonyms SM04690; SM-04690; SM 04690;Lorecivivint;
Formula C29H24FN7O M. Wt 505.56
  • Biological Activity
Description Adavivint is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. Adavivint enhances aggregation of human mesenchymal stem cells (hMSCs) with an EC50 of 10 nM. Adavivint (30 nM) protects chondrocytes from catabolic breakdown in vitro.
Pathways Wnt/Stem Cell 
Targets Wnt 

Structure

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