Vebicorvir
| CAS No. | 2090064-66-5 | Cat. No. | BCP36939 |
| Name | Vebicorvir | ||
| Synonyms | ABI H0731; ABI-H0731; ABIH0731; ABIH 0731; ABIH-0731; ABI H 0731; ABI H-0731; | ||
| Formula | C19H12F3N3O4S2 | M. Wt | 467.44 |
| Description | Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity. ABI-H0731 exhibited selective inhibition of HBV DNA replication (50% effective concentration [EC50] from 173 nM to 307 nM). Most importantly, ABI-H0731 suppressed covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM. Mechanism-of-action studies indicated that ABI-H0731 is a direct-acting antiviral that targets HBV core protein, preventing HBV pregenomic RNA (pgRNA) encapsidation and subsequent DNA replication. | ||
| Pathways | Microbiology/Virology | ||
| Targets | HBV | ||
Structure
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