CTPI-2
| CAS No. | 68003-38-3 | Cat. No. | BCP37418 |
| Name | CTPI-2 | ||
| Synonyms | ABD-7; ABD 7; ABD7; RAS inhibitor Abd-7; CTPI2; CTPI 2; | ||
| Formula | C13H10ClN2O6S | M. Wt | 357.75 |
| Description | CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Mitochondrial Metabolism | ||
Structure
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