AZD-8529
| CAS号 | 1092453-15-0 | 货号 | BCP37625 |
| 中文名 | AZD-8529 | ||
| 英文名 | AZD-8529 | ||
| 中文别名 | |||
| 英文别名 | AZD8529; AZD 8529; | ||
| 分子式 | C24H24F3N5O3 | 分子量 | 487.47 |
| 生物活性 | AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention. | ||
| 信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | mGluR | ||
结构式
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