SW155246
| CAS No. | 420092-79-1 | Cat. No. | BCP37840 |
| Name | SW155246 | ||
| Synonyms | SW-155246;SW 155246; | ||
| Formula | C16H11ClN2O5S | M. Wt | 378.79 |
| Description | SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1) with IC50 value of 1.2 μM, displaying 30-fold selectivity for inhibition of human DNMT1 versus human or murine DNMT3A or -3B. It was shown to inhibit global methylation in HeLa cells, and reactivate expression of the tumor suppressor gene RASSF1A in A549 cells. | ||
| Pathways | Epigenetics | ||
| Targets | DNA Methyltransferase | ||
Structure
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