CMPD101
| CAS No. | 865608-11-3 | Cat. No. | BCP37871 |
| Name | CMPD101 | ||
| Synonyms | CMPD 101; CMPD-101; Takeda101; Takeda-101; Takeda 101; | ||
| Formula | C24H21F3N6O | M. Wt | 466.47 |
| Description | CMPD101 is a novel, potent and selective G-protein coupled receptor kinase 2 and 3 (GRK2/GRK3) inhibitor (IC50 values are 35 and 32 nM at GRK2 and GRK3 respectively). CMPD101 exhibits selectivity for GRK2/3 over GRK1/5 and reduces DAMGO-induced desensitization and internalization of μ-opioid receptors. CMPD101 has been shown to potentiate phosphatidylinositol 4,5-bisphosphate (PIP2) depletion and slow agonist-induced desensitization of protease-activated receptor 2 (PAR2). | ||
| Pathways | Cell Cycle/DNA Damage TGF beta/Smad Wnt/Stem Cell Epigenetics | ||
| Targets | ROCK PKC | ||
Structure
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