TMP778
| CAS No. | 1422171-08-1 | Cat. No. | BCP37895 |
| Name | TMP778 | ||
| Synonyms | TMP 778; TMP-778; | ||
| Formula | C31H30N2O4 | M. Wt | 494.59 |
| Description | TMP778 is a selective RORγt inverse agonist. TMP778 can selectively block mouse Th17 cell differentiation in vitro and impair Th17 cell development in vivo upon immunization with the myelin antigen MOG35-55 plus complete Freund's adjuvant. In addition, TMP778 can repress the expression of more than 150 genes, most of which fall outside the canonical Th17 transcriptional signature and are linked to a variety of inflammatory pathologies in humans. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | ROR | ||
Structure
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