GSK-963
| CAS号 | 2049868-46-2 | 货号 | BCP37994 |
| 中文名 | GSK-963 | ||
| 英文名 | GSK-963 | ||
| 中文别名 | |||
| 英文别名 | GSK 963; GSK963; | ||
| 分子式 | C14H18N2O | 分子量 | 230.31 |
| 生物活性 | GSK-963 is a potent and selective inhibitor of RIP1 kinase. GSK'963 is significantly more potent than Nec-1 in both biochemical and cellular assays, inhibiting RIP1-dependent cell death with an IC50 of between 1 and 4 nM in human and murine cells. GSK'963 is >10 000-fold selective for RIP1 over 339 other kinases, lacks measurable activity against IDO and has an inactive enantiomer, GSK'962, which can be used to confirm on-target effects. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | RIP | ||
结构式
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