NIK SMI1
| CAS No. | 1660114-31-7 | Cat. No. | BCP38023 |
| Name | NIK SMI1 | ||
| Synonyms | NIKSMI1; NIK-SMI1;NIK inhibitor 4f; | ||
| Formula | C20H19N3O4 | M. Wt | 365.39 |
| Description | NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM; only inhibits 3 out of 222 off-target kinases (KHS1, LRRK2, and PKD1) with >75% inhibition at 1 uM; potently inhibits anti-LTβR-induced nuclear p52 levels in anti-LTβR-stimulated HeLa cells, with no effect on canonical signaling; inhibits BAFF and CD40 signaling, suppresses immune responses in vivo; suppresses disease biomarkers and improves survival and renal function in NZB/W F1 mice. | ||
| Pathways | NFκB | ||
| Targets | NF κB | ||
Structure
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