雷西莫特盐酸盐
| CAS号 | 1313757-36-6 | 货号 | BCP38086 |
| 中文名 | 雷西莫特盐酸盐 | ||
| 英文名 | Resiquimod HCl | ||
| 中文别名 | |||
| 英文别名 | R-848; R 848; R848; S 28463; S-28463; S28463; VML-600; VML600; VML 600; | ||
| 分子式 | C17H23ClN4O2 | 分子量 | 350.85 |
| 生物活性 | Resiquimod is a n imidazoquinolinamine Toll-like receptor (TLR) agonist with potential immunostimulatory activity. Resiquimod binds to and activates TLRs 7 and 8, mainly on dendritic cells (DCs), macrophages, and B-lymphocytes, which results in the activation of the TLR signaling pathway and nuclear translocation of the transcription activator NF-kB another transcription factors; subsequently, the production of cytokines, especially interferon-alpha (INF-a), increases, enhancing T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate Langerhans cells, which may result in enhanced activation of T-lymphocytes. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | TLR | ||
结构式
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