西奥骨化醇
| CAS号 | 134404-52-7 | 货号 | BCP38354 |
| 中文名 | 西奥骨化醇 | ||
| 英文名 | Seocalcitol | ||
| 中文别名 | |||
| 英文别名 | EB-1089;EB 1089;EB1089; | ||
| 分子式 | C30H46O3 | 分子量 | 454.68 |
| 生物活性 | Seocalcitol is a vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, seocalcitol may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | Vitamin D Related | ||
结构式
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