GSK2798745
| CAS号 | 1419609-94-1 | 货号 | BCP38659 |
| 中文名 | GSK2798745 | ||
| 英文名 | GSK2798745 | ||
| 中文别名 | |||
| 英文别名 | GSK-2798745; GSK 2798745; | ||
| 分子式 | C25H28N6O3 | 分子量 | 460.53 |
| 生物活性 | GSK2798745 is a potent and selective TRPV4 Ion Channel Inhibitor with IC50 = 1.8 nM. GSK2798745 is potentially useful for the treatment of pulmonary edema associated with congestive heart failure. GSK2798745 demonstrated efficacy in an in vivo rat PK/PD model of pulmonary edema, excellent TRP selectivity (M5, A1, C3, and C6 > 25 μM), and an adequate preclinical safety profile that enabled its candidate selection and subsequent progression to clinical trials. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | TRP Channel | ||
结构式
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