R-1479
| CAS号 | 478182-28-4 | 货号 | BCP38817 |
| 中文名 | R-1479 | ||
| 英文名 | R-1479 | ||
| 中文别名 | 4-叠氮基胞嘧啶核苷; | ||
| 英文别名 | R 1479; R1479; 4'-Azidocytidine; 4'-c-Azidocytidine; | ||
| 分子式 | C9H12N6O5 | 分子量 | 284.23 |
| 生物活性 | R-1479 is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC(50) = 1.28 microM). The corresponding 5'-triphosphate derivative (R1479-TP) is a potent inhibitor of native HCV replicase isolated from replicon cells and of recombinant HCV polymerase (NS5B)-mediated RNA synthesis activity. R1479-TP inhibited RNA synthesis as a CTP-competitive inhibitor with a K(i) of 40 nM. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | HCV | ||
结构式
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