5-Hydroxymethyl-2'-deoxyuridine
| CAS No. | 5116-24-5 | Cat. No. | BCP38821 |
| Name | 5-Hydroxymethyl-2'-deoxyuridine | ||
| Synonyms | alpha-Hydroxythymidine;5-Hydroxymethyldeoxyuridine; | ||
| Formula | C10H14N2O6 | M. Wt | 258.23 |
| Description | 5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM). 5-(Hydroxymethyl)-2'-deoxyuridine acts synergistically with 5-fluorouracil (5-FU) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts. | ||
| Pathways | Microbiology/Virology | ||
| Targets | HSV | ||
Structure
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